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代谢组学引导的基因组比较揭示哺乳动物冬眠基因的趋同进化
研究人员通过分析黑熊冬眠与苏醒期的代谢组数据,结合120种哺乳动物基因组比较,发现38个与肉碱代谢相关的基因在冬眠物种中呈现趋同选择特征,揭示了冬眠过程中代谢重编程、氧化应激和组织保护的分子机制,为开发模拟冬眠状态的临床疗法提供了新靶点。该研究发表于《Molecular Biology and Evolution》。
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