However, PyScript acts as a wrapper, allowing you to embed Python code directly between py-script tags and have it automatically executed by Pyodide.

In Python, the mere act of making a function call incurs a relatively large amount of overhead. If some function is called repeatedly in a tight loop, even if it isn’t a long-running function ...

If you can find a way to speed up the implementation of that loop — say, by using Python built-ins instead of handwritten code — you could get a measurable performance improvement.